The expression of the KAI1 gene, a tumor metastasis suppressor, is directly activated by p53
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منابع مشابه
The expression of the KAI1 gene, a tumor metastasis suppressor, is directly activated by p53.
KAI1 is a tumor metastasis suppressor gene that is capable of inhibiting the metastatic process in animals. The expression of the KAI1 gene also is found to be down-regulated during the tumor progression of prostate, breast, lung, bladder, and pancreatic cancers in humans, and this down-regulation appears to be at or posttranscription level. We have found that the tumor suppressor gene p53 can ...
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Introduction. Uveal melanoma (UM) is an intraocular tumor that leads to metastatic disease in approximately 50% of afflicted patients. There is no efficacious treatment for metastatic disease in this cancer. Identification of markers that can offer prognostic and therapeutic value is a major focus in this field at present. KAI1 is a metastasis suppressor gene that has been reported to play a ro...
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Arnold J. Levine, 1. Cathy A. Finlay, 2 and Philip W. Hinds 3 1Institute for Advanced Study Einstein Drive Princeton, New Jersey 08540 and Cancer Institute of New Jersey 195 Little Albany St. New Brunswick, New Jersey 08903 2 Department of High Throughput Biology GlaxoSmithKline 5 Moore Drive Research Triangle Park, North Carolina 27709 3Harvard Medical School Department of Pathology Armenise 4...
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Background & Aims: KAI1 is a tumor suppressor gene and inhibitor of metastasis in a wide range of malignancies. While it is ubiquitously expressed in normal tissues, KAI1 expression is down regulated in tumors. The present research proposal aims semi quantitative evaluation of KAI1 mRNA expression in Iranian patients with Squamous Cell Carcinoma of Esophagus(SCCE) on finding a correlation betw...
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Hepatitis B virus (HBV) X gene is known to exhibit a transcriptional activation function and is considered to play a major role in hepatocarcinogenesis. We determined a 20-bp promoter element for the HBV X gene transcription and found a binding protein to this promoter element, designated as an X-PBP. We then examined the effects of HBV X protein and p53 tumor suppressor gene product on X gene ...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1998
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.95.19.11307